The combination of mitragynine and morphine prevents the development of morphine tolerance in mice

• Main Authors: Fakurazi, Sharida, Abdul Rahman, Shamima, Baharuldin, Mohamad Taufik Hidayat, Ithnin, Hairuszah, Mohd Moklas, Mohamad Aris, Arulselvan, Palanisamy
• Format: Article
• Language: English
• Published: MDPI 2013
• Online Access: http://psasir.upm.edu.my/id/eprint/29542/1/29542.pdf; http://psasir.upm.edu.my/id/eprint/29542/; http://www.mdpi.com/1420-3049/18/1/666

Mitragynine (MG) is the major active alkaloid found in Mitragyna speciosa Korth. In the present study, we investigated the enhancement of analgesic action of MG when combined with morphine and the effect of the combination on the development of tolerance towards morphine. Mice were administered intr...