Correlation of toluene safe duration (hours/day) and glutathione concentration, malondialdehyde and neurotoxic symptoms in Osowilangun shoe home industry workers

• Main Authors: Ningrum, Diah Pramesthi, Tualeka, Abdul Rohim, Jalaludin, Juliana, Russeng, Syamsiar S., Rahmawati, Pudji, Ahsan, Ahsan, Susilowati, Indah
• Format: Article
• Language: English
• Published: Indian Journal of Forensic Medicine and Toxicology 2020
• Online Access: http://psasir.upm.edu.my/id/eprint/88284/1/ABSTRACT.pdf; http://psasir.upm.edu.my/id/eprint/88284/; https://medicopublication.com/index.php/ijfmt/article/view/11602

Introduction: Exposure of toluene can cause a decrease in glutathione concentration, increase in malondialdehyde and neurotoxic symptoms. The safe duration of toluene in hours/day for each person can vary. The purpose of this study is to determine the relationship between the safe duration of toluene (hours/day) with the concentration of glutathione, malondialdehyde and neurotoxic symptoms in Osowilangun shoe home industry workers. Methods: This research was observational with quantitative approach and cross-sectional design. The sampling technique used was accidental sampling with 25 respondents. The variables studied were safe toluene duration (hours/day), glutathione concentration, malondialdehyde concentration, and neurotoxic symptoms. Data were analyzed using Pearson and Phi correlation. Result: The average of safe duration was 1,489 hours/day, glutathione concentration was 58,349 µg/L, and malondialdehyde was 7,847 MU. As many as 11 out of 14 workers experienced neurotoxic symptoms. The relationship between safe duration (hours/day) with glutathione concentration (r=0.139) and malondialdehyde (r=-0.146) was very weak. While, the relationship between safe duration (hours/day) and neurotoxic symptoms was weak (?=-0.223). Conclusion: The relationship between safe duration in hours/day with glutathione concentration and malondialdehyde was very weak, while relationship with neurotoxic symptoms was weak.