Correlation of toluene safe duration (hours/day) and glutathione concentration, malondialdehyde and neurotoxic symptoms in Osowilangun shoe home industry workers
Introduction: Exposure of toluene can cause a decrease in glutathione concentration, increase in malondialdehyde and neurotoxic symptoms. The safe duration of toluene in hours/day for each person can vary. The purpose of this study is to determine the relationship between the safe duration of toluen...
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Main Authors: | , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Indian Journal of Forensic Medicine and Toxicology
2020
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Online Access: | http://psasir.upm.edu.my/id/eprint/88284/1/ABSTRACT.pdf http://psasir.upm.edu.my/id/eprint/88284/ https://medicopublication.com/index.php/ijfmt/article/view/11602 |
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Summary: | Introduction: Exposure of toluene can cause a decrease in glutathione concentration, increase in malondialdehyde and neurotoxic symptoms. The safe duration of toluene in hours/day for each person can vary. The purpose of this study is to determine the relationship between the safe duration of toluene (hours/day) with the concentration of glutathione, malondialdehyde and neurotoxic symptoms in Osowilangun shoe home industry workers. Methods: This research was observational with quantitative approach and cross-sectional design. The sampling technique used was accidental sampling with 25 respondents. The variables studied were safe
toluene duration (hours/day), glutathione concentration, malondialdehyde concentration, and neurotoxic symptoms. Data were analyzed using Pearson and Phi correlation. Result: The average of safe duration was 1,489 hours/day, glutathione concentration was 58,349 µg/L, and malondialdehyde was 7,847 MU. As many as 11 out of 14 workers experienced neurotoxic symptoms.
The relationship between safe duration (hours/day) with glutathione concentration (r=0.139) and malondialdehyde (r=-0.146) was very weak. While, the relationship between safe duration (hours/day) and
neurotoxic symptoms was weak (?=-0.223). Conclusion: The relationship between safe duration in hours/day with glutathione concentration and malondialdehyde was very weak, while relationship with neurotoxic symptoms was weak. |
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