Analytical method development and validation of anticancer agent, 5-fluorouracil, and its metabolites in biological matrices: an updated review

• Main Authors: Semail, Nadhiratul farihin, Abdul Keyon, Aemi Syazwani, Saad, Bahruddin, Noordin, Siti Salmah, Nik Mohamed Kamal, Nik Nur Syazni, Mohamad Zain, Nur Nadhirah, Azizi, Juzaili, Kamaruzaman, Sazlinda, Yahaya, Noorfatimah
• Format: Article
• Language: English
• Published: Taylor and Francis 2020
• Online Access: http://psasir.upm.edu.my/id/eprint/87877/1/ABSTRACT.pdf; http://psasir.upm.edu.my/id/eprint/87877/; https://www.tandfonline.com/doi/abs/10.1080/10826076.2020.1781654

5-fluorouracil (5-FU) refers to a fluorinated pyrimidine analogue that has been widely used as an anticancer agent for colon, head, and neck cancers. Detection of 5-FU and its metabolites; 5-fluorouridine and 5-fluoro-2-deoxyuridine in biological samples allows optimization of pharmacotherapy and en...