10H‐3,6‐Diazaphenothiazines triggered the mitochondrial‐dependent and cell death receptor‐dependent apoptosis pathways and further increased the chemosensitivity of MCF‐7 breast cancer cells via inhibition of AKT1 pathways

• Main Authors: Ren, Guanghui, Hao, Xiaoyan, Yang, Shuyi, Chen, Jun, Qiu, Guobin, Ang, Kok Pian, Mohd Tamrin, Mohd Islahuddin
• Format: Article
• Language: English
• Published: John Wiley and Sons 2020
• Online Access: http://psasir.upm.edu.my/id/eprint/87563/1/ABSTRACT.pdf; http://psasir.upm.edu.my/id/eprint/87563/; https://onlinelibrary.wiley.com/doi/full/10.1002/jbt.22544

Breast cancer is one of the leading causes of death in cancer categories, followed by lung, colorectal, and ovarian among the female gender across the world. 10H-3,6-diazaphenothiazine (PTZ) is a thiazine derivative compound that exhibits many pharmacological activities. Herein, we proceed to invest...