REST and neural gene network Dysregulation in iPSC models of Alzheimer’s disease

• Main Authors: Meyer, Katharina, Feldman, Heather M., Lu, Tao, Drake, Derek, Lim, Elaine T., Ling, King Hwa, Bishop, Nicholas A., Pan, Ying, Seo, Jinsoo, Lin, Yuan Ta, Su, Susan C., Church, George M., Tsai, Li Huei, Yankner, Bruce A.
• Format: Article
• Language: English
• Published: Cell Press 2019
• Online Access: http://psasir.upm.edu.my/id/eprint/82010/1/REST%20and%20neural%20gene%20network%20.pdf; http://psasir.upm.edu.my/id/eprint/82010/; https://www.cell.com/cell-reports/fulltext/S2211-1247(19)30032-4?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2211124719300324%3Fshowall%3Dtrue

The molecular basis of the earliest neuronal changes that lead to Alzheimer’s disease (AD) is unclear. Here, we analyze neural cells derived from sporadic AD (SAD), APOE4 gene-edited and control induced pluripotent stem cells (iPSCs). We observe major differences in iPSC-derived neural progenitor (N...