Impaired neural stress resistance and loss of REST in bipolar disorder

• Main Authors: Meyer, Katharina, Ling, King-Hwa, Yeo, Pei-Ling, Spathopoulou, Angeliki, Drake, Derek, Choi, Jaejoon, Aron, Liviu, Garcia-Corral, Mariana, Ko, Tak, Lee, Eunjung Alice, Tam, Jenny M., Perlis, Roy H., Church, George M., Tsai, Li-Huei, Yankner, Bruce A.
• Format: Article
• Published: Springer Nature 2023
• Online Access: http://psasir.upm.edu.my/id/eprint/110232/; https://www.nature.com/articles/s41380-023-02313-7

Neurodevelopmental changes and impaired stress resistance have been implicated in the pathogenesis of bipolar disorder (BD), but the underlying regulatory mechanisms are unresolved. Here we describe a human cerebral organoid model of BD that exhibits altered neural development, elevated neural netwo...