Perturbed metabolic profiles associated with muscle weakness seen in adult Ts1Cje mouse model of Down syndrome

• Main Authors: Lim, Chai Ling, Bala, Usman, Leong, Melody Pui Yee, Yap, Ivan Kok Seng, Stanslas, Johnson, Ramasamy, Rajesh, Ling, King-Hwa, Cheah, Pike See
• Format: Article
• Language: English
• Published: Hokkaido University * Graduate School of Veterinary Medicine 2019
• Online Access: http://psasir.upm.edu.my/id/eprint/81687/1/Perturbed%20metabolic%20profiles.pdf; http://psasir.upm.edu.my/id/eprint/81687/; https://eprints.lib.hokudai.ac.jp/dspace/handle/2115/72749

Down syndrome (DS) is a genetic condition resulting from a partial or full triplication of human chromosome 21. Besides intellectual disability, DS is frequently associated with hypotonia. Ts1Cje, mouse model of DS, displays the muscle weakness characteristic. The metabolic profiles of the skeletal...