Association of HTRA1 and ARMS2 gene polymorphisms with response to intravitreal ranibizumab among neovascular age-related macular degenerative subjects
Background: The association of HTRA1 rs11200638 and ARMS2 rs10490924 gene polymorphisms with response to intravitreal ranibizumab therapy among neovascular AMD (nAMD) subjects in Malaysia was determined in this study, followed by the expression of HTRA1 and ARMS2 genes. Results: Both single nucleoti...
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Henry Stewart Publications
2019
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Online Access: | http://psasir.upm.edu.my/id/eprint/80758/1/HTRA.pdf http://psasir.upm.edu.my/id/eprint/80758/ https://pubmed.ncbi.nlm.nih.gov/30795802/ |
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my.upm.eprints.807582020-10-15T22:19:24Z http://psasir.upm.edu.my/id/eprint/80758/ Association of HTRA1 and ARMS2 gene polymorphisms with response to intravitreal ranibizumab among neovascular age-related macular degenerative subjects Mohamad, Nur Afiqah Ramachandran, Vasudevan Mohd Isa, Hazlita Chan, Yoke Mun Ngah, Nor Fariza Ching, Siew Mooi Fan, Kee Hoo Wan Sulaiman, Wan Aliaa Inche Mat, Liyana Najwa Mohamed, Mohd Hazmi Background: The association of HTRA1 rs11200638 and ARMS2 rs10490924 gene polymorphisms with response to intravitreal ranibizumab therapy among neovascular AMD (nAMD) subjects in Malaysia was determined in this study, followed by the expression of HTRA1 and ARMS2 genes. Results: Both single nucleotide polymorphisms (SNPs) recorded a significant association between nAMD and controls with HTRA1 rs11200638 at P = 0.018 (OR = 1.52, 95% CI = 1.07-215) and ARMS2 rs10490924 at P < 0.001 (OR = 2.44, 95% CI = 1.75-3.42). An association was also observed in response to ranibizumab for both SNPs in a logistic regression analysis (P < 0.001). The mRNA levels in the HTRA1 variant between responder and non-responder groups were significantly different for the homozygous non-risk GG genotype (P = 0.032). Conclusions: The HTRA1 rs11200638 and ARMS2 rs10490924 gene polymorphisms are associated with nAMD among Malaysians. Both gene polymorphisms were also correlated with response to intravitreal ranibizumab therapy based on visual and anatomical outcomes especially the HTRA1 rs11200638 variant. Henry Stewart Publications 2019 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/80758/1/HTRA.pdf Mohamad, Nur Afiqah and Ramachandran, Vasudevan and Mohd Isa, Hazlita and Chan, Yoke Mun and Ngah, Nor Fariza and Ching, Siew Mooi and Fan, Kee Hoo and Wan Sulaiman, Wan Aliaa and Inche Mat, Liyana Najwa and Mohamed, Mohd Hazmi (2019) Association of HTRA1 and ARMS2 gene polymorphisms with response to intravitreal ranibizumab among neovascular age-related macular degenerative subjects. Human Genomics, 13 (13). pp. 1-12. ISSN 1473-9542; ESSN: 1479-7364 https://pubmed.ncbi.nlm.nih.gov/30795802/ 10.1186/s40246-019-0197-3 |
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Background: The association of HTRA1 rs11200638 and ARMS2 rs10490924 gene polymorphisms with response to intravitreal ranibizumab therapy among neovascular AMD (nAMD) subjects in Malaysia was determined in this study, followed by the expression of HTRA1 and ARMS2 genes. Results: Both single nucleotide polymorphisms (SNPs) recorded a significant association between nAMD and controls with HTRA1 rs11200638 at P = 0.018 (OR = 1.52, 95% CI = 1.07-215) and ARMS2 rs10490924 at P < 0.001 (OR = 2.44, 95% CI = 1.75-3.42). An association was also observed in response to ranibizumab for both SNPs in a logistic regression analysis (P < 0.001). The mRNA levels in the HTRA1 variant between responder and non-responder groups were significantly different for the homozygous non-risk GG genotype (P = 0.032). Conclusions: The HTRA1 rs11200638 and ARMS2 rs10490924 gene polymorphisms are associated with nAMD among Malaysians. Both gene polymorphisms were also correlated with response to intravitreal ranibizumab therapy based on visual and anatomical outcomes especially the HTRA1 rs11200638 variant. |
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Article |
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Mohamad, Nur Afiqah Ramachandran, Vasudevan Mohd Isa, Hazlita Chan, Yoke Mun Ngah, Nor Fariza Ching, Siew Mooi Fan, Kee Hoo Wan Sulaiman, Wan Aliaa Inche Mat, Liyana Najwa Mohamed, Mohd Hazmi |
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Mohamad, Nur Afiqah Ramachandran, Vasudevan Mohd Isa, Hazlita Chan, Yoke Mun Ngah, Nor Fariza Ching, Siew Mooi Fan, Kee Hoo Wan Sulaiman, Wan Aliaa Inche Mat, Liyana Najwa Mohamed, Mohd Hazmi Association of HTRA1 and ARMS2 gene polymorphisms with response to intravitreal ranibizumab among neovascular age-related macular degenerative subjects |
author_facet |
Mohamad, Nur Afiqah Ramachandran, Vasudevan Mohd Isa, Hazlita Chan, Yoke Mun Ngah, Nor Fariza Ching, Siew Mooi Fan, Kee Hoo Wan Sulaiman, Wan Aliaa Inche Mat, Liyana Najwa Mohamed, Mohd Hazmi |
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Mohamad, Nur Afiqah |
title |
Association of HTRA1 and ARMS2 gene polymorphisms with response to intravitreal ranibizumab among neovascular age-related macular degenerative subjects |
title_short |
Association of HTRA1 and ARMS2 gene polymorphisms with response to intravitreal ranibizumab among neovascular age-related macular degenerative subjects |
title_full |
Association of HTRA1 and ARMS2 gene polymorphisms with response to intravitreal ranibizumab among neovascular age-related macular degenerative subjects |
title_fullStr |
Association of HTRA1 and ARMS2 gene polymorphisms with response to intravitreal ranibizumab among neovascular age-related macular degenerative subjects |
title_full_unstemmed |
Association of HTRA1 and ARMS2 gene polymorphisms with response to intravitreal ranibizumab among neovascular age-related macular degenerative subjects |
title_sort |
association of htra1 and arms2 gene polymorphisms with response to intravitreal ranibizumab among neovascular age-related macular degenerative subjects |
publisher |
Henry Stewart Publications |
publishDate |
2019 |
url |
http://psasir.upm.edu.my/id/eprint/80758/1/HTRA.pdf http://psasir.upm.edu.my/id/eprint/80758/ https://pubmed.ncbi.nlm.nih.gov/30795802/ |
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1681490820350345216 |
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13.18916 |