Asiatic acid stabilizes cytoskeletal proteins and prevents TNF-α-induced disorganization of cell-cell junctions in human aortic endothelial cells

• Main Authors: Yong, Yoke Keong, Fong, Lai Yen, Abdullah, Muhammad Nazrul Hakim, Ng, Chin Theng, Ahmad, Zuraini
• Format: Article
• Language: English
• Published: Elsevier Masson 2019
• Online Access: http://psasir.upm.edu.my/id/eprint/80724/1/CELL.pdf; http://psasir.upm.edu.my/id/eprint/80724/; https://www.sciencedirect.com/science/article/pii/S1537189118301605

Endothelial hyperpermeability represents an initiating step in early atherosclerosis and it often occurs as a result of endothelial barrier dysfunction. Asiatic acid, a major triterpene isolated from Centella asiatica (L.) Urban, has previously been demonstrated to protect against tumor necrosis fac...