Deregulation of hsa-miR-20b expression in TNF-α-induced premature senescence of human pulmonary microvascular endothelial cells

• Main Authors: Wong, Pooi Fong, Jamal, J., Tong, K.L., Khor, E.S., Yeap, C.E., Jong, H.L., Lee, S.T., Mustafa, Mohd Rais, AbuBakar, Sazaly
• Format: Article
• Published: Elsevier 2017
• Subjects: R Medicine; RM Therapeutics. Pharmacology
• Online Access: http://eprints.um.edu.my/17545/; https://doi.org/10.1016/j.mvr.2017.06.002

miRNAs are important regulators of cellular senescence yet the extent of their involvement remains to be investigated. We sought to identify miRNAs that are involved in cytokine-induced premature senescence (CIPS) in endothelial cells. CIPS was established in young human pulmonary microvascular endo...