Human wharton’s jelly-derived mesenchymal stem cells minimally improve the growth kinetics and cardiomyocyte differentiation of aged murine cardiac c-kit cells in in vitro without rejuvenating effect

• Main Authors: Ng, Wai Hoe, Yong, Yoke Keong, Ramasamy, Rajesh, Ngalim, Siti Hawa, Lim, Vuanghao, Shaharuddin, Bakiah, Tan, Jun Jie
• Format: Article
• Language: English
• Published: MDPI AG 2019
• Online Access: http://psasir.upm.edu.my/id/eprint/80102/1/Human%20wharton%E2%80%99s%20jelly-derived%20mesenchymal%20stem%20cells%20minimally%20improve%20the%20growth%20kinetics%20and%20cardiomyocyte%20differentiation%20of%20aged%20murine%20cardiac%20c-kit%20cells%20in%20in%20vitro%20without%20rejuvenating%20effect.pdf; http://psasir.upm.edu.my/id/eprint/80102/; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6887783/pdf/ijms-20-05519.pdf

Cardiac c-kit cells show promise in regenerating an injured heart. While heart disease commonly affects elderly patients, it is unclear if autologous cardiac c-kit cells are functionally competent and applicable to these patients. This study characterised cardiac c-kit cells (CCs) from aged mice and...