Glioblastoma-associated microglia reprogramming is mediated by functional transfer of extracellular miR-21

• Main Authors: Abels, Erik R., Maas, Sybren L. N., Nieland, Lisa, Wei, Zhiyun, Cheah, Pike See, Tai, Eric, Kolsteeg, Christy-Joy, Dusoswa, Sophie A., Ting, David T., Hickman, Suzanne, El Khoury, Joseph, Krichevsky, Anna M., Broekman, Marike L. D., Breakefield, Xandra O.
• Format: Article
• Published: Cell Press 2019
• Online Access: http://psasir.upm.edu.my/id/eprint/79998/; https://www.sciencedirect.com/science/article/pii/S2211124719310769?via%3Dihub

Gliomas are primary, diffusely infiltrating brain tumors. Microglia are innate immune cells in the CNS and make up a substantial portion of the tumor mass. Glioma cells shape their microenvironment, communicating with and reprogramming surrounding cells, resulting in enhanced angiogenesis, immune su...