Semisynthesis and in vitro anticancer activities of andrographolide analogues

• Main Authors: Jada, Srinivasa Rao, Subur, Genevieve Suseno, Matthews, Charlie, Hamzah, Ahmad Sazali, Lajis, Md Nordin, Saad, Mohammad Said, Stevens, M. F. G., Stanslas, Johnson
• Format: Article
• Language: English; English
• Published: Elsevier 2007
• Online Access: http://psasir.upm.edu.my/id/eprint/7522/1/Semisynthesis%20and%20in%20vitro%20anticancer%20activities%20of%20andrographolide%20analogues.pdf; http://psasir.upm.edu.my/id/eprint/7522/; http://dx.doi.org/10.1016/j.phytochem.2006.11.031

The plant Andrographis paniculata found throughout Southeast Asia contains Andrographolide 1, a diterpenoid lactone, which has antitumour activities against in vitro and in vivo breast cancer models. In the present study, we report on the synthesis of andrographolide derivatives, 3,19-isopropylidene...