Andrographolide as a template in the synthesis of new anticancer agents with potentially novel molecular targets

• Main Authors: Stanslas, Johnson, Lim, Siang Hui, Wong, Charng Choon, Sagineedu, Sreenivasa Rao, Lajis, Nordin
• Format: Article
• Language: English
• Published: Federation of American Societies for Experimental Biology 2010
• Online Access: http://psasir.upm.edu.my/id/eprint/13108/1/Andrographolide%20as%20a%20template%20in%20the%20synthesis%20of%20new%20anticancer%20agents%20with%20potentially%20novel%20molecular%20targets.pdf; http://psasir.upm.edu.my/id/eprint/13108/; http://www.fasebj.org/cgi/content/meeting_abstract/24/1_MeetingAbstracts/773.2

Using andrographolide (AGP) as a template, a series of semisynthetic analogues was synthesised for the discovery of new anticancer agent(s) with improved antitumour selectivity and potency. SRJ09, a lead compound displayed remarkable activity in the National Cancer Institute (NCI) of USA in vitro an...