Overexpression of acetyl-CoA carboxylase in Aspergillus terreus to increase lovastatin production

• Main Authors: Hasan, Hanan, Abd Rahim, Muhammad Hafiz, Campbell, Leona, Carter, Dee, Abbas, Ali, Montoya, Alejandro
• Format: Article
• Language: English
• Published: Elsevier 2018
• Online Access: http://psasir.upm.edu.my/id/eprint/75182/1/Overexpression.pdf; http://psasir.upm.edu.my/id/eprint/75182/; https://www.sciencedirect.com/science/article/abs/pii/S1871678417306763?via%3Dihub

The present work describes the application of homologous recombination techniques in a wild-type Aspergillus terreus (ATCC 20542) strain to increase the flow of precursors towards the lovastatin biosynthesis pathway. A new strain was generated to overexpress acetyl-CoA carboxylase (ACCase) by replac...