Modulatory and regenerative potential of transplanted bone marrow derived mesenchymal stem cells on rifampicin-induced kidney toxicity

• Main Authors: Danjuma, Lawal, Pooi, Ling Mok, Higuchi, Akon, Awang Hamat, Rukman, Seoh, Wei Teh, Avin Ee, Hwan Koh, A.Munusamy, Murugan, Arulselvan, Palanisamy, Rajan, Mariappan, Nambi, Arivudai, Swamy, K. B., Vijayaraman, Kiruthiga, Murugan, A. Munusamy, Natarajaseenivasan, Kalimuthusamy, Kumar Subbiah, Suresh
• Format: Article
• Language: English
• Published: Elsevier 2018
• Online Access: http://psasir.upm.edu.my/id/eprint/75013/1/Modulatory.pdf; http://psasir.upm.edu.my/id/eprint/75013/

Anti-tuberculosis agent rifampicin is extensively used for its effectiveness. Possible complications of tuberculosis and prolonged rifampicin treatment include kidney damage; these conditions can lead to reduced efficiency of the affected kidney and consequently to other diseases. Bone marrow-derived mesenchymal stem cells (BMMSCs) can be used in conjunction with rifampicin to avert kidney damage; because of its regenerative and differentiating potentials into kidney cells. This research was designed to assess the modulatory and regenerative potentials of MSCs in averting kidney damage due to rifampicin-induced kidney toxicity in Wistar rats and their progenies. BMMSCs used in this research were characterized according to the guidelines of International Society for Cellular Therapy.