Zn2+ cross-linked sodium alginate-g-allylamine-mannose polymeric carrier of rifampicin for macrophage targeting tuberculosis nanotherapy

• Main Authors: Praphakar, Rajendran Amarnath, Munusamy, Murugan A., Alarfaj, Abdullah A., Kumar, Suresh, Rajan, Mariappan
• Format: Article
• Language: English
• Published: Royal Society of Chemistry 2017
• Online Access: http://psasir.upm.edu.my/id/eprint/63743/1/Zn2%2B%20cross-linked%20sodium%20alginate-g-allylamine-mannose%20polymeric%20carrier%20of%20rifampicin%20for%20macrophage%20targeting%20tuberculosis%20nanotherapy.pdf; http://psasir.upm.edu.my/id/eprint/63743/

Our aim was to evaluate the capacity of polymeric nanoparticles (PNPs) to selectively deliver an antituberculosis drug (rifampicin; RF) to alveolar macrophages. Anionic biodegradable copolymer sodium alginate-g-allylamine-mannose (SA-g-AA-M) was synthesized by atom transfer free radical polymerizati...