The geranyl acetophenone tHGA attenuates human bronchial smooth muscle proliferation via inhibition of AKT phosphorylation

• Main Authors: Yap, Hui Min, Lee, Yu Zhao, Harith, Hanis Hazeera, Tham, Chau Ling, Cheema, Manraj Singh, Shaari, Khozirah, Israf Ali, Daud Ahmad
• Format: Article
• Language: English
• Published: Nature Publishing Group 2018
• Online Access: http://psasir.upm.edu.my/id/eprint/74185/1/The%20geranyl%20acetophenone%20tHGA%20attenuates%20human%20bronchial%20smooth%20muscle%20proliferation%20via%20inhibition%20of%20AKT%20phosphorylation.pdf; http://psasir.upm.edu.my/id/eprint/74185/; https://www.nature.com/articles/s41598-018-34847-0.pdf

Increased airway smooth muscle (ASM) mass is a prominent hallmark of airway remodeling in asthma. Inhaled corticosteroids and long-acting beta2-agonists remain the mainstay of asthma therapy, however are not curative and ineffective in attenuating airway remodeling. The geranyl acetophenone 2,4,6-tr...