General pathways of pain sensation and the major neurotransmitters involved in pain regulation
Pain has been considered as a concept of sensation that we feel as a reaction to the stimulus of our surrounding, putting us in harm’s way and acting as a form of defense mechanism that our body has permanently installed into its system. However, pain leads to a huge chunk of finances within the hea...
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my.upm.eprints.728242021-03-11T19:32:12Z http://psasir.upm.edu.my/id/eprint/72824/ General pathways of pain sensation and the major neurotransmitters involved in pain regulation Yam, Mun Fei Loh, Yean Chun Tan, Chu Shan Adam, Siti Khadijah Abd Manan, Nizar Basir, Rusliza Pain has been considered as a concept of sensation that we feel as a reaction to the stimulus of our surrounding, putting us in harm’s way and acting as a form of defense mechanism that our body has permanently installed into its system. However, pain leads to a huge chunk of finances within the healthcare system with continuous rehabilitation of patients with adverse pain sensations, which might reduce not only their quality of life but also their productivity at work setting back the pace of our economy. It may not look like a huge deal but factor in pain as an issue for majority of us, it becomes an economical burden. Although pain has been researched into and understood by numerous researches, from its definition, mechanism of action to its inhibition in hopes of finding an absolute solution for victims of pain, the pathways of pain sensation, neurotransmitters involved in producing such a sensation are not comprehensively reviewed. Therefore, this review article aims to put in place a thorough understanding of major pain conditions that we experience—nociceptive, inflammatory and physiologically dysfunction, such as neuropathic pain and its modulation and feedback systems. Moreover, the complete mechanism of conduction is compiled within this article, elucidating understandings from various researches and breakthroughs. MDPI 2018 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/72824/1/General%20pathways%20of%20pain%20sensation.pdf Yam, Mun Fei and Loh, Yean Chun and Tan, Chu Shan and Adam, Siti Khadijah and Abd Manan, Nizar and Basir, Rusliza (2018) General pathways of pain sensation and the major neurotransmitters involved in pain regulation. International Journal of Molecular Sciences, 19 (8). pp. 1-23. ISSN 1661-6596; ESSN: 1422-0067 https://pubmed.ncbi.nlm.nih.gov/30042373/ 10.3390/ijms19082164 |
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Pain has been considered as a concept of sensation that we feel as a reaction to the stimulus of our surrounding, putting us in harm’s way and acting as a form of defense mechanism that our body has permanently installed into its system. However, pain leads to a huge chunk of finances within the healthcare system with continuous rehabilitation of patients with adverse pain sensations, which might reduce not only their quality of life but also their productivity at work setting back the pace of our economy. It may not look like a huge deal but factor in pain as an issue for majority of us, it becomes an economical burden. Although pain has been researched into and understood by numerous researches, from its definition, mechanism of action to its inhibition in hopes of finding an absolute solution for victims of pain, the pathways of pain sensation, neurotransmitters involved in producing such a sensation are not comprehensively reviewed. Therefore, this review article aims to put in place a thorough understanding of major pain conditions that we experience—nociceptive, inflammatory and physiologically dysfunction, such as neuropathic pain and its modulation and feedback systems. Moreover, the complete mechanism of conduction is compiled within this article, elucidating understandings from various researches and breakthroughs. |
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Article |
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Yam, Mun Fei Loh, Yean Chun Tan, Chu Shan Adam, Siti Khadijah Abd Manan, Nizar Basir, Rusliza |
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Yam, Mun Fei Loh, Yean Chun Tan, Chu Shan Adam, Siti Khadijah Abd Manan, Nizar Basir, Rusliza General pathways of pain sensation and the major neurotransmitters involved in pain regulation |
author_facet |
Yam, Mun Fei Loh, Yean Chun Tan, Chu Shan Adam, Siti Khadijah Abd Manan, Nizar Basir, Rusliza |
author_sort |
Yam, Mun Fei |
title |
General pathways of pain sensation and the major neurotransmitters involved in pain regulation |
title_short |
General pathways of pain sensation and the major neurotransmitters involved in pain regulation |
title_full |
General pathways of pain sensation and the major neurotransmitters involved in pain regulation |
title_fullStr |
General pathways of pain sensation and the major neurotransmitters involved in pain regulation |
title_full_unstemmed |
General pathways of pain sensation and the major neurotransmitters involved in pain regulation |
title_sort |
general pathways of pain sensation and the major neurotransmitters involved in pain regulation |
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MDPI |
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2018 |
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http://psasir.upm.edu.my/id/eprint/72824/1/General%20pathways%20of%20pain%20sensation.pdf http://psasir.upm.edu.my/id/eprint/72824/ https://pubmed.ncbi.nlm.nih.gov/30042373/ |
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