Thymoquinone-rich fraction nanoemulsion (TQRFNE) decreases Aβ40 and Aβ42 levels by modulating APP processing, up-regulating IDE and LRP1, and down-regulating BACE1 and RAGE in response to high fat/cholesterol diet-induced rats

• Main Authors: Ismail, Norsharina, Ismail, Maznah, Azmi, Nur Hanisah, Bakar, Muhammad Firdaus Abu, Yida, Zhang, Abdullah, Maizaton Atmadini, Basri, Hamidon
• Format: Article
• Language: English
• Published: Elsevier 2017
• Online Access: http://psasir.upm.edu.my/id/eprint/63573/1/Thymoquinone-rich%20fraction%20nanoemulsion%20%28TQRFNE%29%20decreases%20A%CE%B240%20and%20A%CE%B242%20levels.pdf; http://psasir.upm.edu.my/id/eprint/63573/; https://www.sciencedirect.com/science/article/pii/S0753332217322990?via%3Dihub

Though the causes of Alzheimer’s disease (AD) are yet to be understood, much evidence has suggested that excessive amyloid-β (Aβ) accumulation due to abnormal amyloid-β precursor protein (APP) processing and Aβ metabolism are crucial processes towards AD pathogenesis. Hence, approaches aiming at APP...