LAT is essential for the mast cell stabilising effect of tHGA in IgE-mediated mast cell activation

• Main Authors: Tan, Ji Wei, Israf, Daud Ahmad, Md Hashim, Nur Fariesha, Cheah, Yoke Kqueen, Harith, Hanis Hazeera, Shaari, Khozirah, Tham, Chau Ling
• Format: Article
• Language: English
• Published: Elsevier 2017
• Online Access: http://psasir.upm.edu.my/id/eprint/62287/1/LAT%20is%20essential%20for%20the%20mast%20cell%20stabilising%20effect%20of%20tHGA%20in%20IgE-mediated%20mast%20cell%20activation.pdf; http://psasir.upm.edu.my/id/eprint/62287/; https://www.sciencedirect.com/science/article/pii/S0006295217305373?via%3Dihub

Mast cells play a central role in the pathogenesis of allergic reaction. Activation of mast cells by antigens is strictly dependent on the influx of extracellular calcium that involves a complex interaction between signalling molecules located within the cells. We have previously reported that tHGA,...