Overcoming the challenge of transduction of human T-cells with chimeric antigen receptor (CAR) specific for ERBB2 antigen

• Main Authors: Munisvaradass, Rusheni, Ding, Shirley Suet Lee, Koh, Avin Ee Hwan, Subbiah, Suresh Kumar, Lim, Moon Nian, Vellasamy, Shalini, Abdullah, Syahril, Alarfaj, Abdullah A., Mok, Pooi Ling
• Format: Article
• Language: English
• Published: Penerbit Universiti Kebangsaan Malaysia 2017
• Online Access: http://psasir.upm.edu.my/id/eprint/60480/1/Overcoming%20the%20challenge%20of%20transduction%20of%20human%20T-cells%20with%20chimeric%20antigen%20receptor%20%28CAR%29%20specific%20for%20ERBB2%20antigen.pdf; http://psasir.upm.edu.my/id/eprint/60480/; http://www.ukm.my/jsm/english_journals/vol46num10_2017/contentsVol46num10_2017.html

Breast cancer is one of the most common malignancies among woman. Decades of scientific study have linked the overexpression of ERBB2 antigen to aggressive tumors. To target aggressive breast cancer, chimeric antigen receptor (CAR) technology can be utilized. For this, human T-cells are transduced w...