2, 4, 6,-trihydroxy- 3-geranylacetophenone (tHGA) inhibits newly synthesized mediators release in IgE-mediated mast cell degranulation

• Main Authors: Tan, Ji Wei, Israf Ali, Daud Ahmad, Shaari, Khozirah, Tham, Chau Ling
• Format: Article
• Language: English
• Published: Microscopy Society Malaysia 2015
• Online Access: http://psasir.upm.edu.my/id/eprint/57687/1/2%2C%204%2C%206%2C-trihydroxy-%203-geranylacetophenone%20%28tHGA%29%20inhibits%20newly%20synthesized%20mediators%20release%20in%20IgE-mediated%20mast%20cell%20degranulation.pdf; http://psasir.upm.edu.my/id/eprint/57687/

Mast cells are important effector cells of the innate immune system and participate in allergy reaction. Upon FCERI aggregation, mast cells secrete preformed mediators such as histamine as well as newly synthesized mediators including prostaglandins, leukotrienes and proinflammatory cytokines. Our p...