New coumarin and dihydrocinnamic acid derivatives from two Malaysian populations of Micromelum minutum

• Main Authors: Rahmani, Mawardi, Yap, Taufiq Yun Hin, Mohd Ismail, Hazar Bebe, Md. Sukari, Mohd Aspollah, Waterman, Peter G.
• Format: Article
• Language: English; English
• Published: Elsevier Science 1994
• Online Access: http://psasir.upm.edu.my/id/eprint/56240/1/New%20coumarin%20and%20dihydrocinnamic%20acid%20derivatives%20from%20two%20Malaysian%20populations%20of%20Micromelum%20minutum.pdf; http://psasir.upm.edu.my/id/eprint/56240/7/1-s2.0-003194229485100X-main.pdf; http://psasir.upm.edu.my/id/eprint/56240/; http://www.sciencedirect.com/science/article/pii/003194229485100X#

Three novel compounds, two compounds and a dihydrocinnamic acid, have been isolated from two collections of Micromelum minutum and identified by means of NMR spectroscopy. A sample collected from Pahang gave the typical coumarin micromelin and a new dihydrocinnamic acid derivative of micromelin which was identified as 1,2-seco-dihydromicromelin. The second sample, collected from Kelantan, gave two new tetracyclic coumarins, microminutinin and 6-methoxymicrominutinin, which possess a fused bifurano system that appears to be derived by cyclization of a 7-oxygenated-8-(1,2-dimethyl)propylcoumarin precursor. The structure of microminutinin is revised from that proposed in a previous paper.