Cytotoxic activity of coumarins from Micromelium minutum

• Main Authors: Susidarti, Ratna Asmah, Rahmani, Mawardi, Mohd Ismail, Hazar Bebe, Md. Sukari, Mohd Aspollah, Yap, Taufiq Yun Hin, Ee, Gwendoline Cheng Lian, Ali, Abdul Manaf
• Format: Article
• Language: English
• Published: Informa Healthcare 2009
• Online Access: http://psasir.upm.edu.my/id/eprint/13854/1/Cytotoxic%20activity%20of%20coumarins%20from%20Micromelium%20minutum.pdf; http://psasir.upm.edu.my/id/eprint/13854/; http://informahealthcare.com/doi/abs/10.1080/13880200802436513

The crude petroleum ether and chloroform extracts of Micromelum minutum (G. Frost.) Wright & Arn (Rutaceae) showed strong cytotoxic activity when tested against a T-lymphoblastic leukemia cell line. Further fractionation of the extracts resulted in the isolation of five new coumarins 3″,4″-dihyd...