A semisynthetic diterpenoid lactone inhibits NF-kB signalling to ameliorate inflammation and airway hyperresponsiveness in a mouse asthma model
Andrographolide (AGP) and 14-deoxy-11,12-didehydroandrographolide (DDAG), two main diterpenoid constituents of Andrographis paniculata were previously shown to ameliorate asthmatic symptoms in a mouse model. However, due to inadequacies of both compounds in terms of drug-likeness, DDAG analogues wer...
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Main Authors: | , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2016
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Online Access: | http://psasir.upm.edu.my/id/eprint/54935/1/A%20semisynthetic%20diterpenoid%20lactone%20inhibits%20NF-%CE%BAB%20signalling%20to%20ameliorate%20.pdf http://psasir.upm.edu.my/id/eprint/54935/ |
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