SRS06, a new semisynthetic andrographolide derivative with improved anticancer potency and selectivity, inhibits nuclear factor-kB nuclear binding in the A549 non-small cell lung cancer cell line

• Main Authors: Lim, Jonathan Chee Woei, Jeyaraj, Ethel Jeyaseela, Sagineedu, Sreenivasa Rao, Wong, Wai Shiu Fred, Stanslas, Johnson
• Format: Article
• Language: English
• Published: Karger Publishers 2015
• Online Access: http://psasir.upm.edu.my/id/eprint/46370/1/SRS06%2C%20a%20new%20semisynthetic%20andrographolide%20derivative%20with%20improved%20anticancer%20potency%20and%20selectivity%2C%20inhibits%20nuclear%20factor-kB%20nuclear%20binding%20in%20the%20A549%20non-small%20cell%20lung%20cancer%20cell%20line.pdf; http://psasir.upm.edu.my/id/eprint/46370/; https://www.karger.com/Article/Abstract/370313

Background: Andrographolide has been reported with anticancer and anti-inflammatory properties through the inhibition of the activity of signaling molecules such as v-Src, nuclear factor-κB (NF-κB), STAT3, and PI3K. NF-κB has been proven to promote cancer cell survival, and targeting this pathway wi...