Synthesis of unsymmetrical monocarbonyl curcumin analogues with potent inhibition on prostaglandin E2 production in LPS-induced murine and human macrophages cell lines

• Main Authors: Mohd Aluwi, Mohd Fadhlizil Fasihi, Rullah, Kamal, Mohd Yamin, Bohari, Leong, Sze Wei, Abdul Bahari, Mohd Nazri, Lim, Sock Jin, Mohd Faudzi, Siti Munirah, Jalil, Juriyati, Abas, Faridah, Mohd Fauzi, Norsyahida, Ismail, Nor Hadiani, Jantan, Ibrahim, Lam, Kok Wai
• Format: Article
• Language: English
• Published: Elsevier 2016
• Online Access: http://psasir.upm.edu.my/id/eprint/53971/1/Synthesis%20of%20unsymmetrical%20monocarbonyl%20curcumin%20analogues%20.pdf; http://psasir.upm.edu.my/id/eprint/53971/; https://www.sciencedirect.com/science/article/pii/S0960894X16303249

The syntheses and bioactivities of symmetrical curcumin and its analogues have been the subject of interest by many medicinal chemists and pharmacologists over the years. To improve our understanding, we have synthesized a series of unsymmetrical monocarbonyl curcumin analogues and evaluated their e...