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Tetraprenyltoluquinone, an anticancer compound from Garcinia cowa Roxb induce cell cycle arrest on H460 non small lung cancer cell line

Tetraprenyltoluquinone (TPTQ), isolated compound from stem bark of Garcinia cowa Roxb showed selective cytotoxicity towards H460 lung cancer cell line. We further investigated the ability of this compound in inducing cell cycle arrest by flow cytometry. Cell cycle analysis revealed that TPTQ caused...

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Main Authors: Wahyuni, Fatma Sri, Lim, Siang Hui, Stanslas, Johnson, Lajis, Nordin, Hamidi, Dachriyanus
Format: Article
Language:English
Published: Global Research Online Publishing House 2015
Online Access:http://psasir.upm.edu.my/id/eprint/46511/1/Tetraprenyltoluquinone%2C%20an%20anticancer%20compound%20from%20Garcinia%20cowa%20Roxb%20induce%20cell%20cycle%20arrest%20on%20h460%20non%20small%20lung%20cancer%20cell%20line_New.pdf
http://psasir.upm.edu.my/id/eprint/46511/
https://www.globalresearchonline.net/pharmajournal/vol32iss2.aspx
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spelling my.upm.eprints.465112022-06-20T03:48:47Z http://psasir.upm.edu.my/id/eprint/46511/ Tetraprenyltoluquinone, an anticancer compound from Garcinia cowa Roxb induce cell cycle arrest on H460 non small lung cancer cell line Wahyuni, Fatma Sri Lim, Siang Hui Stanslas, Johnson Lajis, Nordin Hamidi, Dachriyanus Tetraprenyltoluquinone (TPTQ), isolated compound from stem bark of Garcinia cowa Roxb showed selective cytotoxicity towards H460 lung cancer cell line. We further investigated the ability of this compound in inducing cell cycle arrest by flow cytometry. Cell cycle analysis revealed that TPTQ caused cell cycle arrest in G0/G1 phase. Our results indicate that TPTQ induces cell cycle arrest and apoptosis in H-460 cells, suggesting that it might represent a potential new chemotherapeutic agent. Global Research Online Publishing House 2015 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/46511/1/Tetraprenyltoluquinone%2C%20an%20anticancer%20compound%20from%20Garcinia%20cowa%20Roxb%20induce%20cell%20cycle%20arrest%20on%20h460%20non%20small%20lung%20cancer%20cell%20line_New.pdf Wahyuni, Fatma Sri and Lim, Siang Hui and Stanslas, Johnson and Lajis, Nordin and Hamidi, Dachriyanus (2015) Tetraprenyltoluquinone, an anticancer compound from Garcinia cowa Roxb induce cell cycle arrest on H460 non small lung cancer cell line. International Journal of Pharmaceutical Sciences Review and Research, 32 (2). art. no. 27. pp. 166-168. ISSN 0976-044X https://www.globalresearchonline.net/pharmajournal/vol32iss2.aspx
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Tetraprenyltoluquinone (TPTQ), isolated compound from stem bark of Garcinia cowa Roxb showed selective cytotoxicity towards H460 lung cancer cell line. We further investigated the ability of this compound in inducing cell cycle arrest by flow cytometry. Cell cycle analysis revealed that TPTQ caused cell cycle arrest in G0/G1 phase. Our results indicate that TPTQ induces cell cycle arrest and apoptosis in H-460 cells, suggesting that it might represent a potential new chemotherapeutic agent.
format Article
author Wahyuni, Fatma Sri
Lim, Siang Hui
Stanslas, Johnson
Lajis, Nordin
Hamidi, Dachriyanus
spellingShingle Wahyuni, Fatma Sri
Lim, Siang Hui
Stanslas, Johnson
Lajis, Nordin
Hamidi, Dachriyanus
Tetraprenyltoluquinone, an anticancer compound from Garcinia cowa Roxb induce cell cycle arrest on H460 non small lung cancer cell line
author_facet Wahyuni, Fatma Sri
Lim, Siang Hui
Stanslas, Johnson
Lajis, Nordin
Hamidi, Dachriyanus
author_sort Wahyuni, Fatma Sri
title Tetraprenyltoluquinone, an anticancer compound from Garcinia cowa Roxb induce cell cycle arrest on H460 non small lung cancer cell line
title_short Tetraprenyltoluquinone, an anticancer compound from Garcinia cowa Roxb induce cell cycle arrest on H460 non small lung cancer cell line
title_full Tetraprenyltoluquinone, an anticancer compound from Garcinia cowa Roxb induce cell cycle arrest on H460 non small lung cancer cell line
title_fullStr Tetraprenyltoluquinone, an anticancer compound from Garcinia cowa Roxb induce cell cycle arrest on H460 non small lung cancer cell line
title_full_unstemmed Tetraprenyltoluquinone, an anticancer compound from Garcinia cowa Roxb induce cell cycle arrest on H460 non small lung cancer cell line
title_sort tetraprenyltoluquinone, an anticancer compound from garcinia cowa roxb induce cell cycle arrest on h460 non small lung cancer cell line
publisher Global Research Online Publishing House
publishDate 2015
url http://psasir.upm.edu.my/id/eprint/46511/1/Tetraprenyltoluquinone%2C%20an%20anticancer%20compound%20from%20Garcinia%20cowa%20Roxb%20induce%20cell%20cycle%20arrest%20on%20h460%20non%20small%20lung%20cancer%20cell%20line_New.pdf
http://psasir.upm.edu.my/id/eprint/46511/
https://www.globalresearchonline.net/pharmajournal/vol32iss2.aspx
_version_ 1736835689045032960
score 13.211869

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