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Cytotoxicity studies of tetraprelyltoluquinone, a prenilated hydroquinone from Garcina cowa Roxb on H-460, MCF-7 and DU-145

Objective: The aim of the present study was to examine the cytotoxicity of a new ring-reduced tetra prenyltoluquinone (TPTQ), [2E,6E,10E]-(+)-4b-hydroxy-3-methyl-5b-(3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraenyl-2-cyclohexen-1-one against H-460, MCF-7 and DU-145 cell lines. Methods: Different co...

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Main Authors: Wahyuni, Fatma Sri, Stanslas, Johnson, Lajis, Nordin, Hamidi, Dachriyanus
Format: Article
Language:English
Published: Innovare Academic Sciences 2015
Online Access:http://psasir.upm.edu.my/id/eprint/44233/1/Cytotoxicity%20studies%20of%20tetraprelyltoluquinone.pdf
http://psasir.upm.edu.my/id/eprint/44233/
https://innovareacademics.in/journals/index.php/ijpps/article/view/3637
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spelling my.upm.eprints.442332018-01-17T03:34:02Z http://psasir.upm.edu.my/id/eprint/44233/ Cytotoxicity studies of tetraprelyltoluquinone, a prenilated hydroquinone from Garcina cowa Roxb on H-460, MCF-7 and DU-145 Wahyuni, Fatma Sri Stanslas, Johnson Lajis, Nordin Hamidi, Dachriyanus Objective: The aim of the present study was to examine the cytotoxicity of a new ring-reduced tetra prenyltoluquinone (TPTQ), [2E,6E,10E]-(+)-4b-hydroxy-3-methyl-5b-(3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraenyl-2-cyclohexen-1-one against H-460, MCF-7 and DU-145 cell lines. Methods: Different concentrations of TPTQ were subjected to cytotoxicity study by using MTT method and calculate the percentage of cell viability. Results: The results of this study showed that this compound has IC50 value 16.3 ± 3.0 µM in H-460 cancer cell lines without any activities towards another two type of cell lines. Conclusion: TPTQ had selective activity against H-460 cancer cell lines. Innovare Academic Sciences 2015 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/44233/1/Cytotoxicity%20studies%20of%20tetraprelyltoluquinone.pdf Wahyuni, Fatma Sri and Stanslas, Johnson and Lajis, Nordin and Hamidi, Dachriyanus (2015) Cytotoxicity studies of tetraprelyltoluquinone, a prenilated hydroquinone from Garcina cowa Roxb on H-460, MCF-7 and DU-145. International Journal of Pharmacy and Pharmaceutical Sciences, 7 (3). pp. 60-63. ISSN 0975-1491 https://innovareacademics.in/journals/index.php/ijpps/article/view/3637
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Objective: The aim of the present study was to examine the cytotoxicity of a new ring-reduced tetra prenyltoluquinone (TPTQ), [2E,6E,10E]-(+)-4b-hydroxy-3-methyl-5b-(3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraenyl-2-cyclohexen-1-one against H-460, MCF-7 and DU-145 cell lines. Methods: Different concentrations of TPTQ were subjected to cytotoxicity study by using MTT method and calculate the percentage of cell viability. Results: The results of this study showed that this compound has IC50 value 16.3 ± 3.0 µM in H-460 cancer cell lines without any activities towards another two type of cell lines. Conclusion: TPTQ had selective activity against H-460 cancer cell lines.
format Article
author Wahyuni, Fatma Sri
Stanslas, Johnson
Lajis, Nordin
Hamidi, Dachriyanus
spellingShingle Wahyuni, Fatma Sri
Stanslas, Johnson
Lajis, Nordin
Hamidi, Dachriyanus
Cytotoxicity studies of tetraprelyltoluquinone, a prenilated hydroquinone from Garcina cowa Roxb on H-460, MCF-7 and DU-145
author_facet Wahyuni, Fatma Sri
Stanslas, Johnson
Lajis, Nordin
Hamidi, Dachriyanus
author_sort Wahyuni, Fatma Sri
title Cytotoxicity studies of tetraprelyltoluquinone, a prenilated hydroquinone from Garcina cowa Roxb on H-460, MCF-7 and DU-145
title_short Cytotoxicity studies of tetraprelyltoluquinone, a prenilated hydroquinone from Garcina cowa Roxb on H-460, MCF-7 and DU-145
title_full Cytotoxicity studies of tetraprelyltoluquinone, a prenilated hydroquinone from Garcina cowa Roxb on H-460, MCF-7 and DU-145
title_fullStr Cytotoxicity studies of tetraprelyltoluquinone, a prenilated hydroquinone from Garcina cowa Roxb on H-460, MCF-7 and DU-145
title_full_unstemmed Cytotoxicity studies of tetraprelyltoluquinone, a prenilated hydroquinone from Garcina cowa Roxb on H-460, MCF-7 and DU-145
title_sort cytotoxicity studies of tetraprelyltoluquinone, a prenilated hydroquinone from garcina cowa roxb on h-460, mcf-7 and du-145
publisher Innovare Academic Sciences
publishDate 2015
url http://psasir.upm.edu.my/id/eprint/44233/1/Cytotoxicity%20studies%20of%20tetraprelyltoluquinone.pdf
http://psasir.upm.edu.my/id/eprint/44233/
https://innovareacademics.in/journals/index.php/ijpps/article/view/3637
_version_ 1643833717530034176
score 13.211869

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