α-mangostin improves glucose uptake and inhibits adipocytes differentiation in 3T3-L1 cells via PPARgamma, GLUT4, and leptin expressions

• Main Authors: Taher, Muhammad, Mohamed Amiroudine, Mohamed Zaffar Ali, Tengku Zakaria, Tengku Muhamad Faris Syafiq, Deny Susanti,, Jauhari Arief Ichwan, Solachuddin, Kaderi, Mohd Arifin, Ahmed, Qamar Uddin, Zakaria, Zainul Amiruddin
• Format: Article
• Language: English
• Published: Hindawi Publishing Corporation 2015
• Online Access: http://psasir.upm.edu.my/id/eprint/43690/1/123.pdf; http://psasir.upm.edu.my/id/eprint/43690/; http://www.hindawi.com/journals/ecam/2015/740238/

Obesity has been often associated with the occurrence of cardiovascular diseases, type 2 diabetes, and cancer. The development of obesity is also accompanied by significant differentiation of preadipocytes into adipocytes. In this study, we investigated the activity of α-mangostin, a major xanthone...