Differential modulation of immune response and cytokine profiles in the bursae and spleen of chickens infected with very virulent infectious bursal disease virus

• Main Authors: Rasoli, Mehdi, Yeap, Swee Keong, Tan, Sheau Wei, Roohani, Kiarash, Teo, Kristeen Ye Wen, Mohamed Alitheen, Noorjahan Banu, Abd Rahman, Yasmin, Ideris, Aini, Bejo, Mohd Hair, Kaiser, Pete, Omar, Abdul Rahman
• Format: Article
• Language: English
• Published: BioMed Central 2015
• Online Access: http://psasir.upm.edu.my/id/eprint/41941/1/41941.pdf; http://psasir.upm.edu.my/id/eprint/41941/; http://bmcvetres.biomedcentral.com/articles/10.1186/s12917-015-0377-x

Background: Very virulent infectious bursal disease virus (vvIBDV) induces immunosuppression and inflammation in young birds, which subsequently leads to high mortality. In addition, infectious bursal disease (IBD) is one of the leading causes of vaccine failure on farms. Therefore, understanding th...