Overexpression of the JmjC histone demethylase KDM5B in human carcinogenesis: involvement in the proliferation of cancer cells through the E2F/RB pathway

• Main Authors: Hayami, Shinya, Yoshimatsu, Masanori, Veerakumarasivam, Abhimanyu, Unoki, Motoko, Iwai, Yukiko, Tsunoda, Tatsuhiko, Field, Helen I., Kelly, John D ., Neal, David E., Yamaue, Hiroki, Ponder, Bruce A. J., Nakamura, Yusuke, Hamamoto, Ryuji
• Format: Article
• Language: English
• Published: BioMed Central 2010
• Online Access: http://psasir.upm.edu.my/id/eprint/40048/1/Overexpression%20of%20the%20JmjC%20histone.pdf; http://psasir.upm.edu.my/id/eprint/40048/; http://www.molecular-cancer.com/content/9/1/59/abstract

Background: Although an increasing number of histone demethylases have been identified and biochemically characterized, their biological functions largely remain uncharacterized, particularly in the context of human diseases such as cancer. We investigated the role of KDM5B, a JmjC histone demethyla...