Anticancer chiral and racemic ternary copper(II) complexes: Multiple mechanisms and epigenetic histone methyltransferase enzymes as novel targets

• Main Authors: Chan, Cheang Wei, Yong, Chin Yoong, Chang, How Mun, Ng, Pei Ying, Davamani, Fabian, Chitra, Ebenezer, Lee, Vannajan Sanghiran, Tan, Kong Wai, Maah, Mohd Jamil, Ng, Chew Hee
• Format: Article
• Published: Elsevier 2022
• Subjects: QD Chemistry
• Online Access: http://eprints.um.edu.my/33622/

Copper complexes have the potential to overcome the limitations of platinum anticancer drugs and to provide a solution to difficult to cure metastatic breast cancer. The anticancer properties of a set of ternary copper(II) complex salts, viz. Cu(phen)(L-ala)(H2O)]NO3 1, rac-Cu(phen)(ala)(H2O)]NO3 2,...