Synthesis of new 1,2-disubstituted benzimidazole analogs as potent inhibitors of b-Glucuronidase and in silico study

• Main Authors: Muhammad Taha, Aftab Ahmad Khan, Fazal Rahim, Syahrul Imran, Mohammed Salahuddin, Nizam Uddin, Khalid Mohammed Khan, Syed Adnan Ali Shah, Ameeduzzafar Zafar, Zainul Amiruddin Zakaria
• Format: Article
• Language: English; English
• Published: Elsevier B.V. 2022
• Subjects: QD1-999 Chemistry; R5-920 Medicine (General)
• Online Access: https://eprints.ums.edu.my/id/eprint/32642/1/Synthesis%20of%20new%201%2C2-disubstituted%20benzimidazole%20analogs%20as%20potent%20inhibitors%20of%20b-Glucuronidase%20and%20in%20silico%20study.pdf; https://eprints.ums.edu.my/id/eprint/32642/2/Synthesis%20of%20new%201%2C2-disubstituted%20benzimidazole%20analogs%20as%20potent%20inhibitors%20of%20b-Glucuronidase%20and%20in%20silico%20study1.pdf; https://eprints.ums.edu.my/id/eprint/32642/; https://www.sciencedirect.com/science/article/pii/S1878535221005207; https://doi.org/10.1016/j.arabjc.2021.103505

New benzimidazole analogues (1–18) were synthesized and characterized through differ- ent spectroscopic techniques such as 1H NMR, 13C NMR and HREI-MS. All analogues were screened for b-glucuronidase inhibitory potential. All analogues showed varied degree of inhibitory potentials with IC50 values r...