Effect of dabai (Canarium odontophyllum) fruit extract on biochemical parameters of induced obese–diabetic rats

• Main Authors: Mokiran, Nurul Nadirah, Ismail, Amin, Azlan, Azrina, Hamid, Muhajir, Hassan, Fouad Abdulrahman
• Format: Article
• Language: English
• Published: Elsevier 2014
• Online Access: http://psasir.upm.edu.my/id/eprint/37219/1/Effect%20of%20dabai.pdf; http://psasir.upm.edu.my/id/eprint/37219/

Dabai is one of the most popular indigenous fruits in Sarawak, and is rich in various nutrients. In this study, the effect of dabai fruit extract (300 and 600 mg/kg bw) on the biochemical parameters of obese–diabetic (Ob-db) rats was investigated. After a 4-week treatment period, the dabai extract at a concentration of 600 mg/kg bw (equivalent to 20 g of flesh with skin of fresh fruit) showed a pronounced effect in lowering the plasma glucose level compared with 300 mg extract/kg bw (equivalent to 10 g of flesh with skin of fresh fruit). The dabai extract also significantly reduced the plasma cholesterol and low-density lipoprotein (LDL-c) levels and increased high-density lipoprotein (HDL-c). However, the dabai extract did not increase the insulin level but did increase its sensitivity and reduced insulin resistance (HOMA-IR). This study suggests that dabai extract possesses hypocholesterolaemic properties, has a short-term glucose-lowering effect and improves the lipid profile through synergistic effect of various polyphenols.