Unscrambling the effect of C-terminal tail deletion on the stability of a cold-adapted, organic solvent stable lipase from Staphylococcus epidermidis AT2

• Main Authors: Ahmad Kamarudin, Nor Hafizah, Raja Abdul Rahman, Raja Noor Zaliha, Mohamad Ali, Mohd Shukuri, Leow, Thean Chor, Basri, Mahiran, Salleh, Abu Bakar
• Format: Article
• Language: English
• Published: Springer 2014
• Online Access: http://psasir.upm.edu.my/id/eprint/35925/1/Unscrambling%20the%20effect%20of%20C-terminal%20tail%20deletion%20on%20the%20stability%20of%20a%20cold-adapted%2C%20organic%20solvent%20stable%20lipase%20from%20Staphylococcus%20epidermidis%20AT2.pdf; http://psasir.upm.edu.my/id/eprint/35925/; http://link.springer.com/article/10.1007%2Fs12033-014-9753-1

Terminal moieties of most proteins are long known to be disordered and flexible. To unravel the functional role of these regions on the structural stability and biochemical properties of AT2 lipase, four C-terminal end residues, (Ile–Thr–Arg–Lys) which formed a flexible, short tail-like random-coil...