Gamma-tocotrienol acts as a BH3 mimetic to induce apoptosis in neuroblastoma SH-SY5Y cells

• Main Authors: Tan, Jen Kit, Then, Sue Mian, Mazlan, Musalmah, Raja Abdul Rahman, Raja Noor Zaliha, Jamal, Rahman, Wan Ngah, Wan Zurinah
• Format: Article
• Language: English
• Published: Elsevier 2016
• Online Access: http://psasir.upm.edu.my/id/eprint/35197/1/Gamma-tocotrienol%20acts%20as%20a%20BH3%20mimetic%20to%20induce%20apoptosis%20in%20neuroblastoma%20SH-SY5Y%20cells.pdf; http://psasir.upm.edu.my/id/eprint/35197/; http://www.sciencedirect.com/science/article/pii/S0955286316000292

Bcl-2 family proteins are crucial regulators of apoptosis. Both pro- and antiapoptotic members exist, and overexpression of the latter facilitates evasion of apoptosis in many cancer types. Bcl-2 homology domain 3 (BH3) mimetics are small molecule inhibitors of antiapoptotic Bcl-2 family members, an...