Induction of apoptosis in MCF-7 cells via oxidative stress generation, mitochondria-dependent and caspase-independent pathway by ethyl acetate extract of Dillenia suffruticosa and its chemical profile

• Main Authors: Tor, Yin Sim, Saiful Yazan, Latifah, Foo, Jhi Biau, Wibowo, Agustono, Ismail, Norsharina, Cheah, Yoke Kqueen, Abdullah, Rasedee, Ismail, Maznah, Ismail, Intan Safinar, Yeap, Swee Keong
• Format: Article
• Language: English
• Published: Public Library of Science 2015
• Online Access: http://psasir.upm.edu.my/id/eprint/34169/1/journal.pone.0127441.PDF; http://psasir.upm.edu.my/id/eprint/34169/

Dillenia suffruticosa, which is locally known as Simpoh air, has been traditionally used to treat cancerous growth. The ethyl acetate extract of D. suffruticosa (EADs) has been shown to induce apoptosis in MCF-7 breast cancer cells in our previous study. The present study aimed to elucidate the mole...