Induction of cell cycle arrest and apoptosis by copper complex Cu(SBCM)₂ towards oestrogen-receptor positive MCF-7 breast cancer cells

• Main Authors: Jhi, Biau Foo, Li, Shang Ng, Ji, Hui Lim, Pau, Xien Tan, Yan, Zhi Lor, Siau, Jason Ee Loo, May, Lee Low, Lee, Chin Chan, Chaw, Yee Beh, Leong, Sze Wei, Saiful Yazan, Latifah, Yim, Sim Tor, Chee, Wun How
• Format: Article
• Language: English
• Published: Royal Society of Chemistry 2019
• Online Access: http://psasir.upm.edu.my/id/eprint/80244/1/Induction%20of%20cell%20cycle%20arrest%20and%20apoptosis%20by%20copper%20complex%20Cu%28SBCM%29%E2%82%82%20towards%20oestrogen-receptor%20positive%20MCF-7%20breast%20cancer%20cells.pdf; http://psasir.upm.edu.my/id/eprint/80244/; https://pubs.rsc.org/en/content/articlelanding/2019/RA/C9RA03130H#!divAbstract

Copper complexes have the potential to be developed as targeted therapy for cancer because cancer cells take up larger amounts of copper than normal cells. Copper complex Cu(SBCM)2 has been reported to induce cell cycle arrest and apoptosis towards triple-negative breast cancer cells. Nevertheless,...