Use of the curcumin analog BHMC in the treatment of endothelial dysfunction and related disorders
The present invention relates to an analog of curcumin, 2,6-bis-(4-hydroxyl-3-methoxybenzylidine)cyclohexanone (BHMC) or a pharmaceutically acceptable salt, solvate or derivative thereof, for use in treating, preventing or managing endothelial dysfunction and/or a disorder associated with endothelia...
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| Main Authors: | , , , |
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| Format: | Patent |
| Published: |
2012
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| Online Access: | http://psasir.upm.edu.my/id/eprint/33360/ |
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| Summary: | The present invention relates to an analog of curcumin, 2,6-bis-(4-hydroxyl-3-methoxybenzylidine)cyclohexanone (BHMC) or a pharmaceutically acceptable salt, solvate or derivative thereof, for use in treating, preventing or managing endothelial dysfunction and/or a disorder associated with endothelial dysfunction. Furthermore provided are methods of treating, preventing or managing endothelial dysfunction and/or a disorder associated with endothelial dysfunction using BHMC or a pharmaceutically acceptable salt, solvate or derivative thereof. The invention provides also a method for attenuating endothelial dysfunction in an endothelial cell and/or attenuating the hallmarks of endothelial dysfunction in an endothelial cell. |
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