Senescent HUVECs-secreted exosomes trigger endothelial barrier dysfunction in young endothelial cells

• Main Authors: Wong, Pooi Fong, Tong, Kind Leng, Jamal, Juliana, Khor, Eng Soon, Lai, Siew Li, Mustafa, Mohd Rais
• Format: Article
• Published: Leibniz Research Centre for Working Environment and Human Factors 2019
• Subjects: R Medicine
• Online Access: http://eprints.um.edu.my/23160/; https://www.excli.de/vol18/Wong_03092019_proof.pdf

Accumulation of senescent endothelial cells can cause endothelium dysfunction which eventually leads to agerelated vascular disorders. The senescent-associated secretory phenotype (SASP) cells secrete a plethora of soluble factors that negatively influence the surrounding tissue microenvironment. Th...