Synthesis, antibacterial activity and cytotoxicity of new fused pyrazolo[1,5-a]pyrimidine and pyrazolo[5,1-c][1,2,4]triazine derivatives from new 5-aminopyrazoles

• Main Authors: Al-Adiwish, Wedad M., Mohamed Tahir, Mohamed Ibrahim, Adnan, Siti Noor Adnalizawati, Hashim, Siti Farah, Ibrahim, Nazlina, Yaacob, W. A.
• Format: Article
• Language: English
• Published: Elsevier 2013
• Online Access: http://psasir.upm.edu.my/id/eprint/30098/1/Synthesis.pdf; http://psasir.upm.edu.my/id/eprint/30098/

New 5-aminopyrazoles 2a–c were prepared in high yields from the reaction of known α,α-dicyanoketene-N,S-acetals 1a–c with hydrazine hydrate under reflux in ethanol. These compounds were utilized as intermediates to synthesize pyrazolo[1,5-a]-pyrimidines 3a–c, 4a–d, 5a–c, and 6a–c, as well as pyrazol...