Evaluation of biological activities of Alpinia mutica Roxb. and its chemical constituents

• Main Authors: Mustahil, Noorul Adawiyah, Sukari, Mohd Aspollah, Abdul, Ahmad Bustamam, Ali, Nor Azah, Ee, Gwendoline Cheng Lian
• Format: Article
• Language: English; English
• Published: University of Karachi. Faculty of Pharmacy 2013
• Online Access: http://psasir.upm.edu.my/id/eprint/30037/1/Evaluation%20of%20biological%20activities%20of%20Alpinia%20mutica%20Roxb.pdf; http://psasir.upm.edu.my/id/eprint/30037/

Phytochemicals investigation on rhizomes of Alpinia mutica has afforded five compounds namely 5,6-dehydrokawain (1), flavokawin B (2), pinostrobin (3) and pinocembrin (4) together with β-sitosterol (5). All crude extracts of the plant demonstrated strong cytotoxicity against CEMss (human T4 lymphoblastoid) cancer cells with IC50 values less than 19 µg/mL, while flavokawin B (2) was the most cytotoxic isolate with IC50 value 1.86±0.37 µg/mL. Most of the crude extracts and isolated compounds showed weak activity in antimicrobial and diphenylpicrylhydrazyl (DPPH) radical scavenging activity tests.