Evaluation of biological activities of Alpinia mutica Roxb. and its chemical constituents
Phytochemicals investigation on rhizomes of Alpinia mutica has afforded five compounds namely 5,6-dehydrokawain (1), flavokawin B (2), pinostrobin (3) and pinocembrin (4) together with β-sitosterol (5). All crude extracts of the plant demonstrated strong cytotoxicity against CEMss (human T4 lympho...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English English |
| Published: |
University of Karachi. Faculty of Pharmacy
2013
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| Online Access: | http://psasir.upm.edu.my/id/eprint/30037/1/Evaluation%20of%20biological%20activities%20of%20Alpinia%20mutica%20Roxb.pdf http://psasir.upm.edu.my/id/eprint/30037/ |
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| Summary: | Phytochemicals investigation on rhizomes of Alpinia mutica has afforded five compounds namely 5,6-dehydrokawain (1), flavokawin B (2), pinostrobin (3) and pinocembrin (4) together with β-sitosterol (5). All crude
extracts of the plant demonstrated strong cytotoxicity against CEMss (human T4 lymphoblastoid) cancer cells with IC50 values less than 19 µg/mL, while flavokawin B (2) was the most cytotoxic isolate with IC50 value 1.86±0.37 µg/mL.
Most of the crude extracts and isolated compounds showed weak activity in antimicrobial and diphenylpicrylhydrazyl
(DPPH) radical scavenging activity tests. |
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