Antinociceptive activity of a synthetic oxopyrrolidine-based compound, ASH21374, and determination of its possible mechanisms

• Main Authors: Zakaria, Zainul Amiruddin, Sani, Mohammed Hijaz, Mohammat, Mohammed Fazli, Mansor, Nurul Shulehaf, Shaameri, Zurina, Teh, Lay Kek, Salleh, Mohd. Zaki, Hamzah, Ahmad Sazali
• Format: Article
• Language: English
• Published: NRC Research Press 2013
• Online Access: http://psasir.upm.edu.my/id/eprint/29682/1/Antinociceptive%20activity%20of%20a%20synthetic%20oxopyrrolidine.pdf; http://psasir.upm.edu.my/id/eprint/29682/; http://www.nrcresearchpress.com/doi/abs/10.1139/cjpp-2013-0099?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed&#.VV7J5vmqqko

This study was carried out to determine the antinociceptive activity of a novel synthetic oxopyrrolidine-based compound, (2R,3R,4S)-ethyl 4-hydroxy-1,2-dimethyl-5-oxopyrrolidine-3-carboxylate (ASH21374), and to elucidate the involvement of the opioid, vanilloid, glutamate, and nitric oxide – cyclic...