Involvement of monoaminergic system in the antidepressant-like effect of aqueous extract of Channa striatus in mice

• Main Authors: Saleem, A. M., Baharuldin, Mohamad Taufik Hidayat, Mat Jais, Abdul Manan, Fakurazi, Sharida, Mohd Moklas, Mohamad Aris, Sulaiman, Mohd Roslan, Amom, Zulkhairi, Basir, Rusliza
• Format: Article
• Language: English
• Published: Verduci Editore 2013
• Online Access: http://psasir.upm.edu.my/id/eprint/29532/1/Involvement%20of%20monoaminergic%20system%20in%20the%20antidepressant-like%20effect%20of%20aqueous%20extract%20of%20Channa%20striatus%20in%20mice.pdf; http://psasir.upm.edu.my/id/eprint/29532/; http://www.europeanreview.org/article/4809

BACKGROUND: In our previous study, the aqueous extract of Channa striatus (family: Channidae) fillet (AECSF) showed an antidepressant-like effect in mice. However, the mechanism of the antidepressant-like effect is unknown. AIM: The objective of this study was to explore the involvement of monoamines in the antidepressant-like effect of AECSF in mice. MATERIALS AND METHODS: AECSF was prepared by steaming the fillets of C. striatus. The male ICR mice were pretreated with various monoaminergic antagonists viz., p-chlorophenylalanine (100 mg/kg, i.p.), prazosin (1 mg/kg, i.p.) and yohimbine (1 mg/kg, i.p.), SCH23390 (0.05 mg/kg, s.c.) and sulpiride (50 mg/kg, i.p.) followed by treatment with AECSF and tested in tail suspension test (TST). Two-way ANOVA with Tukey test were used at p < 0.05 for significance. RESULTS: The pretreatments with p-chlorophenylalanine, prazosin and yohimbine, but not with SCH23390 and sulpiride, were able to reverse the antidepressant-like effect of AECSF in TST. CONCLUSIONS: The antidepressant-like effect of AECSF may be mediated through the serotonergic and noradrenergic systems and not through the dopaminergic system.