Downregulation of RhoGDIα increased migration and invasion of ER+ MCF7 and ER− MDA-MB-231 breast cancer cells.

• Main Authors: Hooshmand, Somayeh, Ghaderi, Abbas, Yusoff, Khatijah, Karrupiah, Thilakavathy, Rosli, Rozita, Mojtahedi, Zahra
• Format: Article
• Language: English; English
• Published: Landes Bioscience 2013
• Online Access: http://psasir.upm.edu.my/id/eprint/28133/1/Downregulation%20of%20RhoGDI%CE%B1%20increased%20migration%20and%20invasion%20of%20ER.pdf; http://psasir.upm.edu.my/id/eprint/28133/; http://www.landesbioscience.com/journals/celladhesion/toc/volume/7/issue/3/

Rho GDp dissociation inhibitors (RhoGDIs) can inhibit cell motility, invasion, and metastasis in cancer by inactivating the RhoGTpases. A member of RhoGDI family has been consistently shown to interact with estrogen receptor (eR), and change its transcriptional activity. eR is a receptor known t...