A Simple and Clean Method for Methoxymethylation of Phenols
A simple and clean procedure for the preparation of methoxymethyl ethers (MOM = CH2 OMe) of phenols having internally hydrogen bonded hydroxy groups is described. Thus treatment of 2,5-dihydroxybenzaldehyde (1) with a 1:1 mixture of methoxymethyl chloride-methyl acetate in ether at room temperatur...
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1989
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| Online Access: | http://psasir.upm.edu.my/id/eprint/2614/1/A_Simple_and_Clean_Method_for_Methoxymethylation_of_Phenols.pdf http://psasir.upm.edu.my/id/eprint/2614/ |
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my.upm.eprints.26142013-05-27T07:02:17Z http://psasir.upm.edu.my/id/eprint/2614/ A Simple and Clean Method for Methoxymethylation of Phenols Ahmad, Faujan Bruce, Malcolm J. A simple and clean procedure for the preparation of methoxymethyl ethers (MOM = CH2 OMe) of phenols having internally hydrogen bonded hydroxy groups is described. Thus treatment of 2,5-dihydroxybenzaldehyde (1) with a 1:1 mixture of methoxymethyl chloride-methyl acetate in ether at room temperature gives 2.5-bis( methoxymethoxy)benzaldehyde (2) in 57% yield; under similar conditions, the methoxymethyl ether (6) of salicylaldehyde was isolated in 75% yield. Yields of61-81 %, not optimised, of methoxymethyl ethers of several phenols lacking internal hydrogen bonding were also obtained. 1989 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/2614/1/A_Simple_and_Clean_Method_for_Methoxymethylation_of_Phenols.pdf Ahmad, Faujan and Bruce, Malcolm J. (1989) A Simple and Clean Method for Methoxymethylation of Phenols. Pertanika, 12 (1). pp. 71-78. English |
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| language |
English English |
| description |
A simple and clean procedure for the preparation of methoxymethyl ethers (MOM = CH2 OMe) of phenols having
internally hydrogen bonded hydroxy groups is described. Thus treatment of 2,5-dihydroxybenzaldehyde (1) with
a 1:1 mixture of methoxymethyl chloride-methyl acetate in ether at room temperature gives 2.5-bis(
methoxymethoxy)benzaldehyde (2) in 57% yield; under similar conditions, the methoxymethyl ether (6) of
salicylaldehyde was isolated in 75% yield. Yields of61-81 %, not optimised, of methoxymethyl ethers of several
phenols lacking internal hydrogen bonding were also obtained. |
| format |
Article |
| author |
Ahmad, Faujan Bruce, Malcolm J. |
| spellingShingle |
Ahmad, Faujan Bruce, Malcolm J. A Simple and Clean Method for Methoxymethylation of Phenols |
| author_facet |
Ahmad, Faujan Bruce, Malcolm J. |
| author_sort |
Ahmad, Faujan |
| title |
A Simple and Clean Method for Methoxymethylation of Phenols |
| title_short |
A Simple and Clean Method for Methoxymethylation of Phenols |
| title_full |
A Simple and Clean Method for Methoxymethylation of Phenols |
| title_fullStr |
A Simple and Clean Method for Methoxymethylation of Phenols |
| title_full_unstemmed |
A Simple and Clean Method for Methoxymethylation of Phenols |
| title_sort |
simple and clean method for methoxymethylation of phenols |
| publishDate |
1989 |
| url |
http://psasir.upm.edu.my/id/eprint/2614/1/A_Simple_and_Clean_Method_for_Methoxymethylation_of_Phenols.pdf http://psasir.upm.edu.my/id/eprint/2614/ |
| _version_ |
1643822370591342592 |
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13.160551 |